| Date | Location | Result | |
| Nov 20, 2010 | Worcester, Mass. | Holy Cross 34, Bucknell 9 | Box score |
| Nov 13, 2010 | Easton, Pa. | Holy Cross 37, Lafayette 27 | Box score |
| Nov 06, 2010 | Worcester, Mass. | Lehigh 34, Holy Cross 17 | Box score |
| Oct 23, 2010 | Hamilton, N.Y. | Holy Cross 31, Colgate 24 | Box score |
| Oct 16, 2010 | Hanover, N.H. | Dartmouth 27, Holy Cross 19 | Box score |
| Oct 09, 2010 | Worcester, Mass. | Holy Cross 17, Brown 13 | Box score |
| Oct 02, 2010 | Worcester, Mass. | Holy Cross 36, Fordham 31 | Box score |
| Sep 25, 2010 | Washington, D.C. | Georgetown 17, Holy Cross 7 | Box score |
| Sep 18, 2010 | Cambridge, Mass. | Harvard 34, Holy Cross 6 | Box score |
| Sep 11, 2010 | Amherst, Mass. | Massachusetts 31, Holy Cross 7 | Box score |
| Sep 04, 2010 | Worcester, Mass. | Holy Cross 38, Howard 7 | Box score |